Providers might refer to corticosteroids as glucocorticoids or the shortened term steroids. All of those names mean any synthetic medicines that cut back irritation in your body. They’re artificial (human-made) medication that are much like cortisol, a hormone your physique naturally produces. Corticosteroids have an analogous anti-inflammatory effect all through your physique, however in a way your supplier can change and modify to go well with your needs. Prednisone belongs to a class of medicine referred to as corticosteroids, that are a kind of steroids. For example, prednisone is usually used to treat the inflammation of rheumatoid arthritis and allergic asthma. Prednisone modifies the immune response of your physique to numerous medical circumstances to attenuate irritation, rashes, swelling and allergic reactions. In distinction with the adverse impact on LDL- and HDL-cholesterol, AAS seem to exert a impartial or favorable impact on lipoprotein (a) (Lp(a)). If you are already taking steroid tablets, ask your physician or a pharmacist for recommendation earlier than taking some other medicines, treatments or supplements. Taking too many steroid tablets over a long period can make you more likely to get unwanted facet effects. Gynecomastia is the benign enlargement of the glandular tissue of the breast (197). The situation is not to be confused with pseudogynecomastia, additionally referred to as lipomastia or adipomastia, during which excessive adipose tissue offers the appearance of gynecomastia. Nonetheless, even after esterification of testosterone by an 11-carbon carboxylic acid group (undecanoate), oral bioavailability remains poor at 6.8% (9). The formulation additionally exhibits large intra- and interindividual variation in bioavailability, making it cumbersome for alternative remedy. To address this, testosterone undecanoate has just lately been formulated in a self-emulsifying drug supply system (SEDDS) to additional improve lymphatic absorption and scale back intra- and interindividual variation (10). However, it must be dosed twice daily to take care of physiological testosterone levels all through the day. An different technique facilities round significantly retarding metabolism of the compound. This structural modification greatly will increase oral bioavailability, although it comes with hepatotoxicity (11). After you cease taking prednisone, especially in excessive doses, your physique might need a hard time making cortisol once more. Importantly, deepening of the voice is thought to be irreversible (88). The lack of evidence however, some AAS users resort to ancillary medication ? corresponding to minoxidil and the 5α-reductase inhibitors finasteride and dutasteride ? to counteract potential hair loss. While the effectiveness of 5α-reductase inhibitors is clear in clinical practice (75), their use within the context of high dosages of testosterone and/or other AAS is unproven and dubious at finest. Any DHT-lowering impact might be easily compensated for by the elevated androgenic action of supraphysiological circulating testosterone ranges. One notable exception is nandrolone, which is transformed into dihydronandrolone (DHN) by 5α-reductase. Nonetheless, whereas testosterone is transformed into the more potent androgen DHT by 5α-reductase (21), the conversion of nandrolone into DHN yields an androgen with considerably lower binding affinity for the AR (77, 78). Thus, whereas testosterone’s actions could be amplified in tissues expressing 5α-reductase, nandrolone’s actions could be diminished (21). By inihibiting glucocorticoids, anabolic steroids shorten the catabolic section of metabolism. That means your muscles spend less time recovering between workouts, and you can do extra with less rest. The route of administration for corticosteroids is dependent upon many components, primarily being the dysfunction treated. The route can be parenteral, oral, inhaled, topical, injected (intramuscular, intraarticular, intralesional, intradermal, and so forth.), and rectal. The clinician must hold many components in thoughts upon deciding to provoke corticosteroid therapy, including the route of administration, preparation, dosing, frequency, and period of therapy. When that is achieved, the dose is gradually reduced until the therapy is finally stopped. Research suggest that one in five people on high-dose prednisone will achieve 22 or extra kilos after one year of treatment (although the weight tends to stabilize after the primary six months). You ought to start to experience back pain reduction within 2?3 days after beginning oral steroids. The greatest use of steroids for again ache could additionally be as a half of a mixture of treatments that embody heat and cold packs, bodily remedy, and complementary treatments, similar to massage or acupuncture. A 2022 examine suggests that steroids could also be most effective for short-term again pain reduction and delaying surgical procedure, but there nonetheless isn’t enough knowledge to show that there are many long-term benefits. People rarely expertise heavy bleeding or infection on the injection web site. Proviron is a steroid that has some particular uses, specifically, how it helps enhance free testosterone. Proviron is useful for longer cycles the place you want to scale back estrogen concerns, add some muscle definition, or help boost the libido. It is even included as a PCT compound because of its minimal opposed effect on luteinizing and follicle-stimulating hormones. Masteron won’t provide you with estrogen ache and may end up in elevated free testosterone, with users often reporting enhanced libido in consequence. On the opposite hand, Masteron does have some androgenic downsides, so hair loss and possible prostate progress can be issues, particularly when using Masteron for a long term. As indicated by our checks, anabolic steroids can certainly construct muscle mass quicker than any natural means of muscle enhancement. Learning, for example, how pain may feel post-injection in comparability with what an infection seems like can mean the difference between making a call to get medical help or knowing that you’ll heal naturally. This comes with time and expertise, but information is energy, and the extra you understand about what can go incorrect, the less chance you’ll have of seeing any severe issues. This ranges from injecting into the wrong spot or too usually in the identical spot, inflicting ache, irritation, or an infection, to much more critical points like by chance injecting right into a vein and placing your life in danger. But by sticking with known, respected, and trusted sources, you should be in a position to remain confident that you just won’t be throwing cash at scammers or counterfeiters. These are just a few of the things that can go incorrect when injecting steroids. Most people will expertise a difficulty one way or another when using steroids over many years.
posted by Willie 2025-06-02 01:31:03.624219
Moreover, I think the tradition of steroids creates unrealistic expectations for newcomers within the health group. It sends the message that progress is unimaginable with out chemical enhancement, which I essentially oppose. Health ought to be about self-discipline, good coaching, and celebrating pure progress, not relying on synthetic boosts that hurt your physique and mind. These clarifications do not diminish the overall validity of Dr. Israetel's message about steroid risks, however they assist present a more complete picture of the present understanding in the area. Since massive doses of AAS are administered during an AAS cycle, it is evident that the development of gynecomastia throughout AAS use just isn't the end result of an absolute or relative deficiency of androgenic action. Estradiol levels improve dose-dependently with testosterone administration; nevertheless, the increase is of proportionately lesser magnitude with rising doses, indicating saturation of aromatase activity (23). As such, it appears affordable to conclude that an absolute extra of estrogenic action causes the development of gynecomastia throughout AAS use, no matter its relative action in contrast with androgens. Some preliminary information regarding the time course of HPGA restoration after AAS use have recently been printed (176). When gonadal operate was regular earlier than an AAS cycle, there was a 90% probability of having normal testosterone ranges three months after cessation and a 100% chance on the end of follow-up (1 yr after the beginning of the cycle). At the group level, imply testosterone levels returned to baseline 3 months after cessation. Importantly, 37% of the themes had indicators of irregular gonadal perform at baseline of which 95% had a historical past of AAS use. The consumption of anabolic steroids has been shown to intervene with the body’s common hormone synthesis. Nonetheless, lowered sperm making, lowered function of the testicles that results in low testosterone ranges, and shrinkage of the testicles, are all adjustments that may be reversed. Each excessive and low HDL ldl cholesterol intensities escalate the possibility of developing atherosclerosis, a scenario the place fatty tissues accumulate in the arteries and cause blood move to be disrupted. Bear in thoughts, the guts is a muscle in itself and the more testosterone present within the body, the extra this muscle can grow (hence why men typically have bigger hearts than women). The risks of an enlarged coronary heart embody heart assault and CAD (coronary artery disease) ? that is from blocked arteries in the coronary heart and hypertension. Elderly sufferers usually endure from a variety of ailments and polypharmacy. Sufferers treated orally with adrenergic beta-receptor blocking medicine ("beta blockers") are at- threat of antagonistic cardiac results if ophthalmic timolol is allotted. In some at-risk patients it is even really helpful that ECG should be registered prior to the initiation of ophthalmic remedy with timolol or betaoxol [11]. Even in apparently healthy subjects, adrenergic beta-antagonists have induced marked bradycardia, even other arrhythmias and probably also bronchoconstriction and hypotension, especially if administered in combination with other cardiovascular or psychoactive drugs. The want for quick muscle gain usually blinds folks to the risk of serious unwanted effects. Issues can embrace heart problems, hormonal imbalance, and liver harm. There is also the question of utilizing testosterone-boosting anabolic steroids as a method to kickstart muscle growth, and how that performs into diabetes. Usually, individuals don’t realize there’s cortisone or one other kind of steroid in [another medication]. Corticosteroid medicines embrace cortisone, hydrocortisone and prednisone. They are helpful in treating rashes, inflammatory bowel illness, bronchial asthma and other conditions. Thus AAS use must be strongly discouraged in those that develop polycythemia. Alternatively, therapeutic phlebotomy might be thought-about for many who, towards higher judgment, continue AAS use for prolonged intervals of time. Nonetheless, it stays to be decided whether therapeutic phlebotomy impacts scientific endpoints similar to MACE and VTE or solely ‘treats’ a laboratory abnormality. The useful impact of therapeutic phlebotomy on clinical outcomes in polycythemia vera patients (53) should not directly be assumed to carry true on this group of sufferers due to the differences in pathophysiology. Nonprescription doses are sometimes 10 to 100 instances greater than the doses healthcare suppliers prescribe to deal with medical situations. The prospective nature, complete evaluation and long follow-up make the results of this trial significantly interesting. The findings were largely just like what had been seen in earlier methodologically weaker research. LVEF decreased by 5%-point and left atrium quantity, LV mass, posterior wall thickness and interventricular septum thickness were elevated on the end of the AAS cycle (Figure 6). The ratio of early (E) to late (A) ventricular filling velocity, or E/A ratio, decreased by 0.forty five. Nevertheless, this does not preclude the possibility that these adjustments would possibly turn into permanent with more extended AAS use or with repeated cycles that present too little time for restoration to happen in between. This is especially worrisome as there might be appreciable evidence that myocardial injury, which may accumulate in years of ongoing AAS use, is a major cause for sudden cardiac demise in AAS users (217). This pathway is particularly relevant for testosterone (yielding 17β-estradiol). Most different AAS aren't a substrate for aromatase or are transformed at lower charges, though the latter group can nonetheless yield a substantial quantity of estrogen if administered in excessive doses. The produced estrogen subsequently exerts its effects by binding to estrogen receptors α and β, thereby diversifying the organic results of the parent compound. Estrogen manufacturing is very relevant in gentle of the development of gynecomastia and the negative endocrine feedback exerted on the hypothalamic?pituitary?gonadal axis (HPGA). We describe its role herein in additional detail within the subsections on Gynecomastia and Testosterone Deficiency. AAS are most commonly administered by intramuscular (i.m.) injection or by oral ingestion. Injection are primarily based on vegetable oils, similar to arachis oil, by which AAS are dissolved. On the surface, steroid users would possibly appear extra confident as a end result of their enhanced physique. But beneath that muscular exterior often lies a fragile vanity, closely dependent on their bodily look. Social situations turn into minefields of potential judgment and comparability. Now, let’s discuss what occurs upstairs when you’re pumping your body full of steroids.
posted by Cinda 2025-05-23 09:25:31.784191
In 2014, I began taking a low dose of hormones to achieve delicate masculinizing results, a course of that I name microdosing testosterone (or "T"). Relating To surgical options, metoidioplasty is a process obtainable for transmasculine people. This surgery involves making a phallus from the existing genital tissue, enhanced by the consequences of testosterone. It’s a choice for those looking for additional gender-affirming bodily modifications and can be an essential step in aligning one’s bodily physique with their gender identification. As with any surgery, it’s necessary to discuss the risks, benefits, and expectations with a specialist. In the process of masculinisation, bottom progress can be a significant and affirming change for many transmasculine people. By Way Of hormone remedy, particularly testosterone therapy, this growth is typically initiated, with the extent and price varying among people. Many people on T expertise the slowing-down or even stopping of their intervals, though, like many features of T, this differs based on dosing and timing. For these whose durations are uncomfortable or dysphoric, this could be a welcome change. However, anticipating this alteration would possibly inform any considerations you've about your reproductive future. "I was actually scared about bottom growth," Schwartz explains, but he says that in hindsight, his fears have been "silly and largely products of my internalized transphobia." The hair follicles that become activated do not go away, and even off T, you will still develop hair in these locations. If you're fearing hair development on T, know that hair removing options like waxing, shaving, or laser/electrolysis hair removing are potential. Somewhat than feeling the slow, building surge of an orgasm, you may find that the experience is abrupt and extra intense. Your capability to have a quantity of orgasms may change, or you may feel so delicate that you just don’t get pleasure from direct contact. Zaps and tingling sensation are a sign of growth that will subside as your bottom growth slows. Hypersensitivity is extra common in the first 3-6 months on testosterone and tends to stabilize after some time. As testosterone impacts your different body parts, you may feel like your clitoris is bigger, firmer, or more responsive. Increased blood move to your intercourse organs might make your clitoris look deep pink or pink. In order to offer healthcare providers to you and give you medically applicable care, we're required to get a recent blood strain reading. You can get your blood stress read free of charge at many pharmacies, go to your major care doctor, or you might buy a blood strain cuff on-line. Testosterone cream is totally different from the Androgel or testosterone gel prescribed for testosterone HRT. Transdermal testosterone gels are water-based and usually comprise a excessive proportion of alcohol, whereas compounded testosterone lotions are an emulsion of water and oil. This signifies that testosterone cream could be less irritating when applied to your genitals vs. testosterone gel. You can pump as incessantly or sometimes as you want, and you need to find a cadence for pumping constantly that works for you. One potential advantage of FTM pumping is its affordability in comparison with other strategies of backside progress enhancement. Penis pumps can often be purchased at comparatively low prices and do not require ongoing bills like hormone remedy does. Some good articles, newspapers, manuals, and books are available on various websites. They cowl trans health research and have useful health and hormone remedy information for FTM people. He also seen hair development across the area and the increase of the vulva and labia. Nevertheless, he's on the lookout for other choices, corresponding to bottom surgical procedure, to ensure that he will get a penis within the space. It’s important to do thorough research and consult with medical professionals earlier than incorporating this method into one’s transition journey. It is necessary to notice that while testosterone does promote these changes, it can not utterly change one’s anatomy. For example, even with HRT, a transgender man won't develop a completely functioning penis or testicles. The extent of backside progress additionally depends on numerous components similar to age at which HRT was started and genetics. The change could happen due to the development of the clitoris, which will increase sensitivity. This piece is part of In Transit, our sequence exploring the ins and outs of transitioning and the way trans and nonbinary folks define it for themselves. All data provided on this web site is meant as a guide only. Please see your physician for specific health recommendation in your individual circumstances. Really Feel free to ask us any question you would like about TRT, medical weightloss, ED, or different matters related to males's health. These photographs of my physique are what I was looking for before I went on testosterone and had prime surgical procedure. I finally got here throughout a zine that mentioned that one of the best place to search out visible representation of transgender our bodies is in porn. The genital dysphoria I used to have has gone away, now that I am masculine and male-passing, and the extra growth may be very pleasurable. As a way of HRT, testosterone impacts someone’s secondary sex traits. In this context, secondary intercourse traits are the modifications to the body during adolescent puberty that can be altered during hormone alternative therapy or HRT. To study more about what secondary sex characteristics are and/or what modifications to anticipate whereas taking testosterone for HRT, go to UCSF’s information to masculinizing hormone remedy. Many sources might help people who discover themselves transitioning or serious about it. In addition to training about hormones, it's also important for those in transition to discover a assist system. Throughout the transition period, it might be comforting and helpful to connect with different transgender folks. You have an unimaginable opportunity to be taught more about yourself, your thoughts, and your coronary heart as your physique transforms. Most testosterone users uncover bottom development by the way it feels lengthy before they observe any outward adjustments. The clitoris is a delicate construction around 4 inches long with roughly eight,000 nerve endings. The visible part of the clitoris may resemble somewhat bud or button, whereas the overwhelming majority of the anatomy is concealed inside the body. Given the possibility that top pelvic flooring muscle tone could trigger pelvic pain, pelvic flooring physical remedy to relax the muscular tissues could also be a useful therapy option to attempt.
posted by Adrianna 2025-05-22 10:39:52.197455
In reality, there is a larger incidence of dementia in individuals with chronically low serotonin levels. There is a agency organic rationale for the view that progesterone performs an essential position in brain perform and there are discernible effects on cognition in animals. Moreover, progesterone exposures are linked to patterns of brain activation during cognitive processing in girls. Cyclic mastalgia isn't thought of as a part of PMS, even though it is certainly associated to the menstrual cycle. It is bilateral, diffuse, poorly localized, and customarily described as soreness that always radiates to the underarms and even down the arms. It happens principally in the course of the luteal part of the menstrual cycle because of increased water content in breast stroma caused by rising hormone ranges. Cyclic breast ache happens extra generally in youthful ladies, typically will resolve spontaneously, and is classed in a different way than as being a half of premenstrual syndrome. Certain health situations can also give way to low ranges of the T hormone, along with different hormones. The team at SynergenX is committed to providing top-notch care and personalised therapy plans that can assist you to feel like yourself once more. With a number of testosterone clinic locations and skilled professionals ready to help you, there’s no better time than now to take management of your well being. But altering hormone ranges could make it tough to precisely determine an androgen deficiency. The normal vary for testosterone in ladies is 15 to 70 ng/dL, however where you fall within that vary may rely on your age and different well being elements. If you are experiencing any of these signs frequently, seek the assistance of a healthcare professional. Blood checks and hormone assessments may help determine the cause of your imbalance, allowing for proper treatment. The pathophysiology of cluster headache is complex and the underlying mechanisms are not totally elucidated. Curious if anyone has handled headaches (more like a low grade headache). It Is not debilitating like a hangover or migraine however definitely new since starting remedy. Obviously, I will focus on with my doctor but once more, curious if that's common at all. The scientific group continues to be exploring the mechanisms behind this potential link, and extra studies are required to validate these findings. Nausea could presumably be an indication of an allergic response to sure elements of testosterone therapies, such because the provider oils in injections. If nausea is accompanied by different symptoms like swelling, itching, or respiration difficulties, seek medical attention instantly. He implements the most superior, state-of-the-art know-how and remedy choices. Dr. Nazarian specializes in bio-identical hormone replacement therapy in males & women. He has in depth training and data in treating andropause and testosterone alternative remedy in men and menopause and estrogen substitute remedy in girls. A healthcare professional might help you find one of the best treatment plan to manage your signs and enhance your quality of life. When somebody has low testosterone, they may expertise many signs, including nausea. Certain components can make some individuals extra prone to have nausea when their testosterone ranges are low. In this part, we are going to explore the factors that would enhance the possibilities of nausea linked to low testosterone. Understanding these elements can help people recognize if they are extra at risk and take steps to manage their symptoms. Nonetheless, testosterone additionally affects other areas, together with the mind and nervous system. The quantity of sleep needed varies amongst people, but most adults want an optimum of seven to 9 hours of sleep per evening. Getting an excellent night’s sleep is a natural method to preserve healthy testosterone levels in younger males. Analysis has shown that even every week of decreased sleep can significantly decrease testosterone ranges, especially in the afternoons and evenings on days with much less sleep. To provide a clearer image, complications are caused by issues within the blood vessels and nerves within the physique.
posted by Angelica 2025-05-22 09:16:13.345504
La libido correspond à l’envie et la volonté d’avoir une activité sexuelle, y compris la masturbation. Le désir sexuel fluctue tout au long de la vie et, parfois, les hommes peuvent souffrir d’une baisse de libido. L’essentiel de cette hormone est produite pendant les phases de sommeil profond, notamment en début de nuit. Évitez les aliments ultra-transformés, riches en sucres ajoutés et en mauvaises graisses, qui perturbent l’équilibre hormonal. Contrairement à ce que l’on pourrait penser, notre corps n’a pas besoin de caféine pour avoir de l’énergie. Réduisez parallèlement votre consommation d’alcool et de sucres raffinés qui perturbent l’équilibre hormonal. Enfin, maintenez un apport calorique suffisant puisqu’une restriction extreme diminue les niveaux de testostérone. Le stress chronique peut avoir des effets dévastateurs sur vos niveaux de testostérone. Le cortisol, l’hormone du stress, peut inhiber la production de testostérone si ses niveaux deviennent trop élevés. La méditation et le yoga sont d’excellentes methods de rest qui peuvent aider à réduire le stress et à stimuler la production de testostérone. Voici 5 conseils efficaces et validés scientifiquement pour stimuler votre manufacturing de testostérone après 50 ans. La maca est une plante originaire des montagnes péruviennes, souvent utilisée pour ses effets bénéfiques sur la libido et l’énergie. Elle a montré qu’elle pouvait améliorer la qualité du sperme et stimuler la production de testostérone. Grâce à sa capacité à équilibrer les hormones, la maca est un complément populaire parmi les hommes cherchant à améliorer leur santé hormonale. Le zinc est un minéral qui joue un rôle majeur dans la production de testostérone. Une carence en zinc peut entraîner une diminution des niveaux de testostérone. En supplémentant votre alimentation avec du zinc, vous pourrez stimuler la production de cette hormone et améliorer vos performances physiques. N’oublie pas non plus l’impact potentiel des compléments alimentaires naturels, tels que Crazy Bulk, TestoPrime, Bulk Excessive et l’Ashwagandha de Natura Drive. Ces produits peuvent aider à stimuler les niveaux de testostérone, à condition qu’ils soient utilisés en complément d’un mode de vie sain. L’activité physique régulière, en particulier l’entraînement en résistance (musculation), peut stimuler la manufacturing de testostérone, indique Charlotte Methorst. Des exercices de développement musculaire comme les squats, les pompes, les burpees, les deadlifts ou les bench press peuvent être particulièrement bénéfiques. Oui, la perte de poids, notamment si vous êtes en surpoids ou obèse, peut augmenter vos niveaux de testostérone. Une combinaison d'exercices réguliers et d'une alimentation équilibrée peut contribuer à la perte de poids et à l'amélioration des taux de testostérone. Limitez cependant vos séances à minutes afin d’éviter l’augmentation du cortisol, hormone antagoniste de la testostérone. Adopter une approche holistique orientée sur la santé générale est essentiel. Allier les différentes stratégies discutées améliore les résultats globaux. En intégrant l’alimentation, l’exercice, la gestion du stress et le sommeil, vous pouvez donner un coup de pouce significatif à votre taux de testostérone. Comme l’explique , cette hormone influence également l’humeur, la motivation, la capacité à gérer le stress et la clarté mentale. Lorsqu’elle est stable, elle favorise une pensée plus structurée, une meilleure gestion des émotions et une vie sexuelle plus épanouie. Elle stimule le désir, renforce l’estime de soi et participe à une sensation générale de bien-être, sans excès ni caricature, mais avec un retour à une harmonie naturelle entre le corps et l’esprit. Si vous cherchez à augmenter naturellement vos niveaux de testostérone, vous êtes au bon endroit. De nombreux compléments alimentaires peuvent vous aider à atteindre cet objectif. Dans cet article, nous vous dévoilons sept compléments naturels que nous vous recommandons pour stimuler la manufacturing de testostérone. En adoptant ces suppléments, vous pourrez maximiser vos résultats tout en préservant votre santé. Il est necessary de préciser que la qualité du lipide est très importante automotive l’on a besoin essentiellement que des acides gras mono-insaturés. L’huile d’olive, les amandes, les noix, les avocats, le beurre de cacahuète, les oléagineux sont des porteurs des acides gras mono-insaturés. On peut aussi quelques fois avoir recours à des acides gras saturés, présents dans la viande rouge, l’huile de coco, le jaune d’œuf, le chocolat noir, et le fromage. Mais, ce qui est clairement démontré, c’est que dormir seulement 5 heures réduit le taux de testostérone de 15 %. Des chercheurs de l’université de Chicago ont effectivement remarqué que le temps de sommeil joue directement sur le niveau de testostérone au réveil. Une étude du NCBI a même révélé que chaque heure de sommeil supplémentaire augmente ce taux de 15 %. Si les symptômes du manque de testostérone sont importants, un bilan hormonal peut permettre d'y voir plus clair et d’éventuellement donner lieu à un traitement à base de testostérone. Le stress chronique entraîne une manufacturing excessive de cortisol, une hormone qui inhibe la testostérone. Avec l’âge, la capacité de récupération diminue et le stress peut avoir un impression plus marqué. Brises donc ce cycle vicieux dès maintenant pour retrouver ton équilibre naturel et augmenter ainsi ton taux de testostérone. Puisqu’on parle de soleil ??, il convient de souligner qu’une carence en vitamine D peut aussi affecter négativement ton taux de testostérone. Alors prends-toi des bains de soleil en été et n’oublie pas de te complémenter en vitamine D durant l’hiver. Essaie d’incorporer souvent ces produits à ton alimentation pour faire progresser ton taux de testostérone.
posted by Kaitlyn 2025-05-19 11:46:11.232898
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